TTK21

SKU: orb1298639

Description

TTK21

Research Area

Epigenetics & Chromatin

Key Properties

• CAS Number: 709676-56-2
• MW: 357.75
• Purity: 98.43%
• Formula: C₁₇H₁₅ClF₃NO₂
• SMILES: CCCOc1ccccc1C(=O)Nc1ccc(Cl)c(c1)C(F)(F)F
• Target: Epigenetic Reader Domain,Histone Acetyltransferase
• Solubility: 10% DMSO+90% Corn Oil:2 mg/mL (5.59 mM);DMSO:25 mg/mL (69.88 mM)

Bioactivity

• In Vivo:
  a small-molecule (TTK21) activator of the histone acetyltransferases CBP/p300, which, when conjugated to glucose-based carbon nanosphere (CSP), passed the blood-brain barrier, induced no toxicity, and reached different parts of the brain. After intraperitoneal administration in mice, CSP-TTK21 significantly acetylated histones in the hippocampus and frontal cortex. Remarkably, CSP-TTK21 treatment promoted the formation of long and highly branched doublecortin-positive neurons in the subgranular zone of the dentate gyrus and reduced BrdU incorporation, suggesting that CBP/p300 activation favors maturation and differentiation of adult neuronal progenitors. In addition, mRNA levels of the neuroD1 differentiation marker and BDNF, a neurotrophin required for the terminal differentiation of newly generated neurons, were both increased in the hippocampus concomitantly with an enrichment of acetylated-histone on their proximal promoter.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CBP/p300, CSP, blood–brain barrier, Inhibitor, Histone Acetyltransferase, histone acetyltransferases, HATs, HAT, EpigeneticReaderDomain, Epigenetic Reader Domain, inhibit, long-term memory, neurogenesis, toxicity, TTK 21, TTK21, TTK-21

Compound Identifiers

PubChem CID

68453302