TSHR antagonist S37

SKU: orb1308988

Description

S37 is a potent, selective, and competitive small molecule antagonist of the thyroid-stimulating hormone receptor (TSHR). It is a valuable research tool for investigating TSHR signaling in vitro and for studying Graves' disease and hyperthyroidism in preclinical models.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1217616-61-9
• MW: 460.57
• Purity: 96.75% (May vary between batches)
• Formula: C₂₅H₂₀N₂O₃S₂
• SMILES: O=C1C2C3C4C(C(C3)C2C(=O)N1C5=CC=CC=C5)SC6=C(C4C7=CC=CC=C7)SC(=O)N6
• Target: TSH Receptor
• Solubility: DMSO:65 mg/mL (141.13 mM)

Bioactivity

• In Vitro:
  cAMP activation induced by the small molecule agonist C2 reduced by TSHR antagonist S37.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

thyrotropin receptor (TSHR), TSHR antagonist S37, TSHR antagonist S-37, TSHReceptor, TSH Receptor, TSHR

Compound Identifiers

PubChem CID

23604673