TRPM4-IN-1

SKU: orb1298248

Description

TRPM4-IN-1

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 351424-20-9
• MW: 340.16
• Purity: 98.75%
• Formula: C₁₅H₁₁Cl₂NO₄
• SMILES: OC(=O)c1ccc(Cl)cc1NC(=O)COc1ccccc1Cl
• Target: TRP/TRPV Channel
• Solubility: DMSO:80 mg/mL (235.18 mM);10% DMSO+90% Corn Oil:3.3 mg/mL (9.7 mM)

Bioactivity

• Target IC50:
  TRPM4:1.5 μM
• In Vitro:
  TRPM4-IN-1 selectively inhibits TRPM4 overexpressed in HEK293 cells. TRPM4-IN-1 inhibits endogenous TRPM4 currents in LNCaP cells. TRPM4-IN-1 restores functional expression of A432T, a loss‐of‐expression TRPM4 variant.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CBA, channel, diseases, cardiac, cation, cancer, calcium-activated, 4-chloro-2-(2-(2-chlorophenoxy)acetamido)benzoic acid, Inhibitor, inhibit, non-selective, prostate, TRPV Channel, TRPVChannel, TRPChannel, TRPM4IN1, TRPM-4-IN-1, TRPM4-IN-1, TRPM4, TRPM4 IN 1, TRP Channel, Transient receptor potential channels

Compound Identifiers

PubChem CID

2264067