Trifluridine

SKU: orb1308655

Description

Trifluridine is a fluorinated thymidine analog with antineoplastic and antiviral properties. It functions by incorporating into DNA and inhibiting thymidylate synthase, thereby disrupting DNA synthesis and inducing apoptosis. This mechanism has been studied in vitro and in vivo for cancer research, particularly in models of colorectal carcinoma and herpesvirus infections.

Research Area

Cell Biology, Infectious Disease & Virology, Molecular Biology

Key Properties

• CAS Number: 70-00-8
• MW: 296.2
• Purity: 99.82% (May vary between batches)
• Formula: C₁₀H₁₁F₃N₂O₅
• SMILES: O=C1N([C@@H]2O[C@H](CO)[C@@H](O)C2)C=C(C(F)(F)F)C(=O)N1
• Target: DNA/RNA Synthesis,Virus Protease,Nucleoside Antimetabolite/Analog,HSV,Apoptosis,Autophagy
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (16.88 mM);H2O:14.8 mg/mL (49.97 mM);DMSO:255 mg/mL (860.9 mM)

Bioactivity

• In Vivo:
  Differences in substrate specificity at TK1 and DUT resulted in substantial Trifluridine (FTD) incorporation into DNA. Trifluridine-treated cells display nuclear morphology compared to 2'-deoxy-5-fluorouridine-treated cells.Trifluridine dose-dependently inhibits the proliferation of human colorectal cancer cells transplanted into nude mice and mouse bone marrow cells.Trifluridine dose-dependently inhibits colony-forming bone marrow cells.
• In Vitro:
  Differences in substrate specificity at TK1 and DUT resulted in substantial Trifluridine (FTD) incorporation into DNA. Trifluridine-treated cells display nuclear morphology compared to 2'-deoxy-5-fluorouridine-treated cells.Trifluridine dose-dependently inhibits the proliferation of human colorectal cancer cells transplanted into nude mice and mouse bone marrow cells.Trifluridine dose-dependently inhibits colony-forming bone marrow cells.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DNASynthesis, DNA Synthesis, DNA/RNA Synthesis, Analog, 5-Trifluorothymidine, HSV, Herpes simplex virus, Inhibitor, Orthopoxvirus, NSC75520, NSC-75520, Nucleoside Antimetabolite, Nucleoside Antimetabolite/Analog, NucleosideAntimetabolite, NSC529182, NSC-529182, NSC 529182, NSC 75520, inhibit, TFT, RNASynthesis, RNA Synthesis, Thymidylate synthase, Thymidylate Synthase, Viroptic, Trifluorothymidine, Trifluridina, Trifluridine

Compound Identifiers

PubChem CID

6256