TREM2-IN-1

SKU: orb2565127

Description

TREM2-IN-1 (OPA) is a platinum-based small molecule that inhibits TREM2 on myeloid cells and exhibits anti-cancer activity by blocking DNA replication. It has been shown in a mouse colorectal cancer model to suppress immune regulatory activity, reducing markers like CD206 and CX3CR1, supporting its use in oncology and immunology research.

Research Area

Cell Biology

Key Properties

• CAS Number: 2000236-36-0
• MW: 1164.12
• Purity: 98.56%
• Formula: C₄₆H₆₈N₂O₂₀Pt
• SMILES: [O-](C(CCC(O[C@@H]1O[C@]2([C@]34[C@]([C@H]1C)(CC[C@@H](C)[C@@]3(CC[C@](C)(O2)OO4)[H])[H])[H])=O)=O)[Pt+4]56([O-]C(CCC(O[C@@H]7O[C@]8([C@]9%10[C@]([C@H]7C)(CC[C@@H](C)[C@@]9(CC[C@](C)(O8)OO%10)[H])[H])[H])=O)=O)([NH2]C%11C([NH2]5)CCCC%11)[O-]C(=O)C(=O)[O-]6
• Target: Apoptosis,Others
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (2.83 mM);DMSO:80 mg/mL (68.72 mM)

Bioactivity

• In Vivo:
  TREM2-IN-1 (1.5 mg Pt per kg, treated, a single dose, lasting 15 days) was effective in inhibiting tumor growth in a C57BL/6 mouse model with MC38 mouse colon cancer and was less toxic overall.
• In Vitro:
  TREM2-IN-1 (0.8 μM, 72 h) inhibited the early phase of DNA synthesis (G1 phase) in HCT-116 cells and had a strong pro-apoptotic ability. Trem2-in-1 (1 μM, 24 h) significantly inhibited the expression of TREM2 IN THP-1-derived macrophages.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

176419014