Tranilast

SKU: orb1305160

Description

Tranilast (SB 252218) is an antiallergic agent that inhibits the release of pro-inflammatory lipid mediators and cytokines from various cell types. Its mechanism supports research into allergic diseases, fibrosis, and restenosis, with applications in both in vitro cellular assays and in vivo animal models.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 53902-12-8
• MW: 327.33
• Purity: >99.99% (May vary between batches)
• Formula: C₁₈H₁₇NO₅
• SMILES: N(C(C=CC1=CC(OC)=C(OC)C=C1)=O)C2=C(C(O)=O)C=CC=C2
• Target: RAAS,Prostaglandin Receptor
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.11 mM);DMSO:50 mg/mL (152.75 mM)

Bioactivity

• Target IC50:
  PGD2:0.1 mM (IC50)
• In Vivo:
  In hypertrophic and proliferative scar tissues, Tranilast ([3-300 mM]) inhibits collagen synthesis in fibroblasts by suppressing the Transforming Growth Factor (TGF)-β1, yet it does not inhibit the fibroblasts in normal skin.
• In Vitro:
  In diabetic rats' hearts, Tranilast reduces the phosphorylation of Smad2, effectively mitigating cardiac fibrosis.

Storage & Handling

• Storage: keep away from direct sunlight,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

microvascular, MK 341, MK341, MK-341, inhibit, Inhibitor, endothelial, factor, growth, chemotaxis, anti-atopic, Angiogenesis, Angiotensin Receptor, Tranilast, SB 252218, SB252218, SB-252218, Prostaglandin Receptor, ProstaglandinReceptor, prostaglandin, proliferation, vascular, tube

Compound Identifiers

PubChem CID

5527