TR antagonist 2

SKU: orb3135640

Description

TR antagonist 2 (Compound 10a) is a competitive inhibitor of thyroid hormone receptors (TRα/β) with an IC50 of 47 nM. It works by competitively binding to the ligand-binding domain of the receptor with triiodothyronine (T3), thereby blocking the formation of the receptor-coactivator complex, inhibiting target gene transcription, and reducing thyroid hormone-mediated metabolic effects. TR antagonist 2 holds potential for research into hyperthyroidism (such as Graves' disease) and thyrotoxicosis.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1073179-55-1
• MW: 463.41
• Formula: C₂₁H₂₀F₃N₅O₄
• SMILES: O=C(NNC(=O)CC1=CCN(C2=CC=C(C=C2)N(=O)=O)CC1)NC3=CC=CC(=C3)C(F)(F)F
• Target: Thyroid hormone receptor(THR)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Thyroid hormone receptor(THR)