TR-107

SKU: orb2308715

Description

TR-107 (Anticancer agent 230) is a potent and selective activator of the mitochondrial protease ClpP. It has demonstrated antitumor efficacy in vivo, inhibiting growth in the MDA-MB-231 xenograft model, and is a valuable tool for studying mitochondrial proteostasis in cancer research.

Research Area

Protein Biochemistry

Key Properties

• CAS Number: 2485052-87-5
• MW: 390.87
• Formula: C₂₂H₁₉ClN₄O
• SMILES: N#CC1=CC=CC(=C1)CN2CC=3C(=O)N(C=NC3CC2)CC4=CC=C(Cl)C=C4
• Target: Protease

Bioactivity

• In Vitro:
  The CFTR corrector 12 , when applied at a concentration of 15 μM for 72 hours, is capable of restoring α-sarcoglycan levels in cells harboring the L31P/V247M α-SG mutations.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

TR107, mitochondrial protease ClpP, Anticancer agent 230

Compound Identifiers

PubChem CID

154694481