TP0472993

SKU: orb1745216

Description

TP0472993 is a potent, orally bioavailable dual inhibitor of CYP4A11 and CYP4F2 with IC50 values of 140 nM and 40 nM, respectively. It demonstrates distribution to tissues like liver and kidney and is a research tool for investigating the role of these enzymes in renal pathophysiology and related metabolic studies.

Research Area

Metabolism Research

Key Properties

• CAS Number: 2126874-77-7
• MW: 300.36
• Purity: 98.65%
• Formula: C₁₆H₂₀N₄O₂
• SMILES: O(CC1CCN(C(C)=O)CC1)C2=CC=C(N=C2)C=3C=CNN3
• Target: Cytochromes P450
• Solubility: DMSO:22.5 mg/mL (74.91 mM);10% DMSO+40% PEG300+5% Tween-80+45% Saline:2 mg/mL (6.66 mM)

Bioactivity

• Target IC50:
  CYP4F2:40 nM|20-HETE:29 nM|CYP4A11:140 nM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CYP4A11/CYP4F2IN2, CYP4A11/CYP4F2-IN-2, CYP450

Compound Identifiers

PubChem CID

130360508