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Torin 2

SKU: orb1301073

Description

Torin 2 is a highly potent and selective mTOR inhibitor with an IC50 of 0.25 nM, exhibiting over 800-fold selectivity against PI3K. It also inhibits ATM, ATR, and DNA-PK with EC50 values of 28, 35, and 118 nM, respectively. This molecule is a valuable chemical probe for studying mTOR signaling and DNA damage response pathways in both cellular and animal models.

Research Area

Cell Biology, Molecular Biology, Signal Transduction

Images & Validation

Key Properties

CAS Number1223001-51-1
MW432.4
Purity99.47% (May vary between batches)
FormulaC24H15F3N4O
SMILESNc1ccc(cn1)-c1ccc2ncc3ccc(=O)n(-c4cccc(c4)C(F)(F)F)c3c2c1
TargetAutophagy,ATM/ATR,mTOR,DNA-PK,Apoptosis

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Key Properties

No computed properties available.

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Torin 2 (orb1301073)

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5 mg
$ 320.00
10 mg
$ 520.00
25 mg
$ 990.00
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