Toloxatone

SKU: orb1301889

Description

Toloxatone is a selective and reversible inhibitor of monoamine oxidase A (MAO-A). It is used in biochemical research to study MAO-A function and has been applied in both in vitro enzyme assays and in vivo models investigating neurotransmitter regulation.

Research Area

Metabolism Research, Neuroscience

Key Properties

• CAS Number: 29218-27-7
• MW: 207.23
• Purity: 99.86% (May vary between batches)
• Formula: C₁₁H₁₃NO₃
• SMILES: Cc1cccc(c1)N1CC(CO)OC1=O
• Target: Monoamine Oxidase,MAO
• Solubility: DMSO:50 mg/mL (241.28 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (9.65 mM)

Bioactivity

• In Vivo:
  The maximum increase in systolic blood pressure produced by four single oral doses of tyramine administered during a meal and ranging from 100 mg to 800 mg was compared during repeated (3 to 5 days) administration of placebo, 200 mg toloxatone three times a day and 400 mg toloxatone three times a day in a single-blind, three-period crossover study. Toloxatone by itself had no significant influence on blood pressure. During administration of toloxatone, no significant increase in tyramine-induced increase in systolic blood pressure was observed for tyramine doses of 200 mg or less that are consistently higher than those associated with normal food intake .

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Toloxatone, Inhibitor, MD69276, MD-69276, MD 69276, MAO, MAO-A, inhibit, Monoamine Oxidase, MonoamineOxidase

Compound Identifiers

PubChem CID

34521