TNG260

SKU: orb1744101

Description

TNG260 is a selective CoREST deacetylase (CoreDAC) inhibitor that potently targets HDAC1 over HDAC3. It reverses STK11 loss-mediated anti-PD1 resistance by modulating the tumor immune microenvironment, reducing neutrophil infiltration and promoting immune-mediated tumor cell killing in preclinical studies.

Research Area

Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 2935964-98-8
• MW: 383.44
• Purity: 99.78% (May vary between batches)
• Formula: C₂₀H₁₈FN₃O₂S
• SMILES: O=C(C1=CC=C(C=C1)S(C)(=N)=O)NC2=C(N)C=CC(C3=CC=C(C=C3)F)=C2
• Target: HDAC

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

168264922