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TNFSF15 Antibody / VEGI / TL1A

Catalog Number: orb386086

DispatchUsually dispatched within 5-10 working days
$ 410.00
Catalog Numberorb386086
CategoryAntibodies
DescriptionTNF ligand-related molecule 1 is an anti-angiogenic cytokine that is also called Tumor necrosis factor superfamily, member 15 (TNFSF15) and Vascular endothelial growth inhibitor (VEGI/VEGI192A). This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Reduced expression of TL1A has been reported as a marker of poor prognosis in breast cancer.
ClonalityMonoclonal
Species/HostMouse
IsotypeMouse IgG1, kappa
ConjugationUnconjugated
ReactivityHuman
ImmunogenA full length human recombinant protein was used as the immunogen for this TL1A antibody.
UniProt IDO95150
Tested applicationsIHC-P
Dilution rangeImmunohistochemistry (FFPE): 1-2ug/ml for 30 min at RT
Application notesTitration of the TL1A antibody may be required for optimal performance.
Antibody TypePrimary Antibody
Clone NumberVEGI/1283
Formula0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Hazard InformationThis TL1A antibody is available for research use only.
NoteFor research use only
TNFSF15 Antibody / VEGI / TL1A

IHC testing of FFPE human parathyroid mass with TL1A antibody (clone VEGI/1283). Required HIER: boil sections in 10mM Tris with 1mM EDTA, pH9, for 10-20 min followed by cooling at RT for 20 min.

TNFSF15 Antibody / VEGI / TL1A

IHC testing of FFPE human colon carcinoma with TL1A antibody (clone VEGI/1283). Required HIER: boil sections in 10mM Tris with 1mM EDTA, pH9, for 10-20 min followed by cooling at RT for 20 min.

TNFSF15 Antibody / VEGI / TL1A

SDS-PAGE Analysis of Purified, BSA-Free TL1A Antibody (clone VEGI/1283). Confirmation of Integrity and Purity of the Antibody.

  • TNFSF15 Antibody / VEGI / TL1A [orb606459]

    IHC-P

    Human

    Rabbit

    Recombinant

    Unconjugated

    20 μg, 100 μg
  • TNFSF15 Antibody / VEGI / TL1A [orb606460]

    IHC-P

    Human

    Mouse

    Recombinant

    Unconjugated

    20 μg, 100 μg
  • TNFSF15 Antibody / VEGI / TL1A [orb534084]

    IHC-P

    Human

    Rabbit

    Recombinant

    Unconjugated

    20 μg, 100 μg
  • TNFSF15 Antibody / VEGI / TL1A [orb376640]

    IHC-P

    Human

    Mouse

    Monoclonal

    Unconjugated

    20 μg, 100 μg
  • TNFSF15 Antibody / VEGI / TL1A [orb1822712]

    IHC-P

    Human

    Rabbit

    Recombinant

    Unconjugated

    100 μg