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TMX1

SKU: orb1982285

Description

TMX1 is a covalent molecular glue that selectively recruits the CUL4-DCAF16 E3 ligase to the BD2 domain of BRD4, inducing its targeted degradation. This tool compound is valuable for probing BRD4 biology and BET protein function in both cellular and in vivo models of oncology and transcriptional regulation.

Research Area

Cell Biology, Epigenetics & Chromatin, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number3079093-92-5
MW476.59
FormulaC26H28N4O3S
TargetOthers
SolubilityDMSO:≥ 80 mg/mL;10% DMSO+40% PEG300+5% Tween-80+45% Saline:3.3 mg/mL (6.92 mM)

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

TMX-1

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Protocol Information