TM5007

SKU: orb1298488

Description

TM5007 is a potent small molecule inhibitor of plasminogen activator inhibitor-1 (PAI-1), exhibiting an IC50 of 29 µM. This inhibitor is a valuable research tool for studying fibrinolysis, thrombosis, and fibrosis in both cellular assays and animal models of related diseases.

Research Area

Metabolism Research

Key Properties

• CAS Number: 342595-05-5
• MW: 560.69
• Purity: 96.91%
• Formula: C₂₄H₂₀N₂O₆S₄
• SMILES: C(O)(=O)C=1C(=CSC1NC(CCCCC(NC2=C(C(O)=O)C(=CS2)C3=CC=CS3)=O)=O)C4=CC=CS4
• Target: PAI-1
• Solubility: DMSO:Slightly soluble

Bioactivity

• Target IC50:
  PAI1:29 uM
• In Vivo:
  In vivo the most effective molecule (TM5007) inhibits coagulation in 2 models: a rat arteriovenous (AV) shunt model and a mouse model of ferric chloride-induced testicular artery thrombosis. It also prevents the fibrotic process initiated by bleomycin in mouse lung.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PAI-1, PAI1, inhibit, Inhibitor, Plasminogen activator inhibitor-1, TM 5007, TM5007, TM-5007

Compound Identifiers

PubChem CID

4199057