Tigogenin

SKU: orb1301524

Description

Tigogenin, a steroidal sapogenin, serves as a key synthetic intermediate for steroid drugs. Research indicates its potential bone-protective properties, with in vitro and in vivo studies exploring its role in osteoporosis prevention and bone metabolism.

Key Properties

• CAS Number: 77-60-1
• MW: 416.64
• Purity: 99.97% (May vary between batches)
• Formula: C₂₇H₄₄O₃
• SMILES: [H][C@]12C[C@@]3([H])[C@]4([H])CC[C@@]5([H])C[C@@H](O)CC[C@]5(C)[C@@]4([H])CC[C@]3(C)[C@@]1([H])[C@H](C)[C@@]1(CC[C@@H](C)CO1)O2
• Target: Others
• Solubility: DMSO:Insoluble;Ethanol:10 mg/mL (24 mM);H2O:Insoluble

Bioactivity

• In Vitro:
  Tigogenin enhanced the proliferation of BMSCs significantly. Tigogenin treatment reduced the adipogenic induction of lipid accumulation, visfatin secretion, and the expressions of peroxisome proliferation-activated receptor (PPAR)gamma2 and adipocyte fatty acid-binding protein (ap)2. Moreover, tigogenin had no effect on the mitotic clonal expansion. On the other hand, tigogenin significantly elevated alkaline phosphatase (ALP) activity and the expressions of Cbfa1, collagen type I (COL I) and osteocalcin (OCN), as well as the content of matrix calcium in BMSCs.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

stromal, Tigogenin, adipocytic, anti-obesity, bone, differentiation, cells, inhibit, osteoblastic, marrow, Inhibitor

Compound Identifiers

PubChem CID

99516