Thyrotropin-Releasing Hormone (TRH), Free Acid

SKU: orb1299848

Description

Thyrotropin-Releasing Hormone Free Acid (TRH-OH) is a key neuropeptide known for its central role in regulating thyroid hormone secretion via feedback mechanisms. It is widely used in neuroscience and endocrinology research, facilitating in vitro receptor binding studies and in vivo investigations of neuroendocrine function.

Key Properties

• CAS Number: 24769-58-2
• MW: 363.37
• Purity: ≥95%
• Formula: C₁₆H₂₁N₅O₅
• SMILES: OC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCC(=O)N1
• Target: Others
• Solubility: DMSO:122.5 mg/mL (337.12 mM)

Bioactivity

• In Vitro:
  Thyrotropin-releasing-hormone (TRH) stimulated the release of newly synthesized GH and PRL, but not thyroid-stimulating hormone. In addition, TRH stimulated a dose-related increase in the release of newly synthesized GH and PRL at 10(-9) to 10(-7) M. Cyclo(His-Pro) stimulated the release of newly synthesized GH dose- dependently. TRH, cyclo(His-Pro), and hGHRH stimulated GH synthesis, while SRIF inhibited this at 10(-7) M. The release of newly synthesized PRL into culture medium was also stimulated by TRH and hGHRH, but inhibited by SRIF. PRL synthesis was not affected by TRH-OH and cyclo(His-Pro). Intracellular contents of GH and PRL in the pituitary did not change significantly.TRH plays an important role in both GH and PRL synthesis and release.

Storage & Handling

• Storage: keep away from moisture | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

TRH-OH, Thyrotropin Releasing Hormone (TRH), Free Acid, Thyrotropin-Releasing Hormone (TRH), ThyrotropinReleasing Hormone (TRH), Free Acid, Thyrotropin-Releasing Hormone (TRH), Free Acid, inhibit, Inhibitor

Compound Identifiers

PubChem CID

10428784