Thymulin

SKU: orb1296317

Description

Thymulin is a nonapeptide hormone secreted by the thymus, recognized for its immunoregulatory and anti-inflammatory properties. It is utilized in immunological research to study T-cell maturation and function in both in vitro assays and in vivo models of inflammation and immune deficiency.

Research Area

Immunology & Inflammation, Signal Transduction

Key Properties

• CAS Number: 63958-90-7
• MW: 858.85
• Purity: 99.56%
• Formula: C₃₃H₅₄N₁₂O₁₅
• SMILES: CC(NC(=O)C1CCC(=O)N1)C(=O)NC(CCCCN)C(=O)NC(CO)C(=O)NC(CCC(N)=O)C(=O)NCC(=O)NCC(=O)NC(CO)C(=O)NC(CC(N)=O)C(O)=O
• Target: ERK,Immunology/Inflammation related
• Solubility: H2O:10 mM;DMSO:Insoluble

Bioactivity

• In Vitro:
  The effects of different doses and various timings of thymulin intraperitoneal administration on spinal microglial activity and intracellular pathways in an inflammatory rat model of Complete Freund's adjuvant (CFA). Thymulin treatment was implemented following CFA-induced inflammation for 21 days. After conducting behavioral tests (edema and hyperalgesia), the cellular and molecular aspects were examined to detect the thymulin effect on inflammatory factors and microglial activity. Demonstrated that thymulin treatment notably reduced thermal hyperalgesia and paw edema induced by CFA. Furthermore, molecular investigations showed that thymulin reduced CFA-induced activation of microglia cells, phosphorylation of p38 MAPK and the production of spinal pro-inflammatory cytokines (TNF-α, IL-6) during the study. Results suggest that thymulin treatment attenuates CFA-induced inflammation. This effect may be mediated by inhibition of spinal microglia and production of central inflammatory mediators which seems to be associated with the ability of thymulin to reduce p38 MAPK phosphorylation. These data provide evidence of the anti-hyperalgesic effect of thymulin on inflammatory pain and characterize some of the underlying spinal mechanisms.

Storage & Handling

• Storage: keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Immunologyrelated, Immunology/Inflammation related, Immunology related, Inflammation related, Inflammationrelated, Thymulin

Chemical strucure of Thymulin

Compound Identifiers

PubChem CID

4277323