Thalidomide-O-amido-PEG2-C2-NH2 TFA

SKU: orb1307440

Description

This compound is a thalidomide-based cereblon E3 ligase ligand conjugated to a short PEG linker, designed for constructing PROTAC molecules. It is widely used in chemical biology and drug discovery research for targeted protein degradation studies in both cellular and preclinical models.

Research Area

Cell Biology, Immunology & Inflammation; Metabolism Research; Pharmacology & Drug Discovery, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1957235-75-4
• MW: 576.48
• Purity: 95.74% (May vary between batches)
• Formula: C₂₃H₂₇F₃N₄O₁₀
• SMILES: O=C(NCCOCCOCCN)COC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O.O=C(O)C(F)(F)F
• Target: E3 Ligase Ligand-Linker Conjugate
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.47 mM);H2O:150 mg/mL (260.2 mM)

Bioactivity

• In Vitro:
  PROTACs consist of two ligands linked together: one binds to an E3 ubiquitin ligase, and the other targets a specific protein. By leveraging the intracellular ubiquitin-proteasome system, PROTACs facilitate the selective degradation of target proteins .
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, E3LigaseLigandLinkerConjugate, E3 Ligase Ligand-Linker Conjugates 24, E3 Ligase Ligand-Linker Conjugates 24 TFA, E3 Ligase Ligand-Linker Conjugates, E3 Ligase Ligand-Linker Conjugate, E3 Ligase LigandLinker Conjugate, Cereblon, Cereblon Ligand-Linker Conjugates 10, Cereblon Ligand-Linker Conjugates 10 TFA, Thalidomide O amido PEG2 C2 NH2 TFA, ThalidomideOamidoPEG2C2NH2 TFA, Thalidomide-O-amido-PEG-2-C2-NH2 TFA, Thalidomide-O-amido-PEG2-C2-NH2 TFA

Compound Identifiers

PubChem CID

121439750