Thalidomide-O-amido-C6-NH2 hydrochloride

SKU: orb1307274

Description

This compound is a thalidomide-based cereblon ligand conjugated to an aminohexyl linker, designed for constructing PROTAC molecules. It serves as a key component in targeted protein degradation research for probing protein function in both cellular and biochemical assays.

Research Area

Cell Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2376990-31-5
• MW: 466.915
• Purity: 97.33% (May vary between batches)
• Formula: C₂₁H₂₇ClN₄O₆
• SMILES: Cl.NCCCCCCNC(=O)COc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12
• Target: Autophagy,E3 Ligase Ligand-Linker Conjugates,Apoptosis

Bioactivity

• In Vitro:
  PROTACs comprise two distinct ligands linked together: one binds to an E3 ubiquitin ligase, while the other targets a specific protein. They harness the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Cereblon, E3 Ligase LigandLinker Conjugate, E3 Ligase Ligand-Linker Conjugate, E3 Ligase Ligand-Linker Conjugates, E3LigaseLigandLinkerConjugate, inhibit, Inhibitor, Thalidomide O amido C6 NH2 hydrochloride, ThalidomideOamidoC6NH2 hydrochloride, Thalidomide-O-amido-C-6-NH2 hydrochloride, Thalidomide-O-amido-C6-NH2 Hydrochloride

Compound Identifiers

PubChem CID

145874886