Thalidomide-O-amido-C3-PEG3-C1-NH2

SKU: orb1691482

Description

This compound is a cereblon (CRBN)-directed E3 ligase ligand-linker conjugate, incorporating a thalidomide-based ligand connected via a triethylene glycol spacer. It is a key component for constructing PROTACs, bifunctional molecules used in chemical biology and drug discovery research to induce targeted protein degradation in both cellular and in vivo models.

Research Area

Cell Biology, Pharmacology & Drug Discovery, Pharmacology & Drug Discovery; Cell Biology

Key Properties

• CAS Number: 1799711-29-7
• MW: 648.589
• Formula: C₂₇H₃₅F₃N₄O₁₁
• SMILES: OC(=O)C(F)(F)F.NCCCOCCOCCOCCCNC(=O)COc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12
• Target: Apoptosis,Autophagy,Others,E3 Ligase Ligand-Linker Conjugates

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

121411156