Thalidomide-NH-C6-NH2 hydrochloride

SKU: orb1940282

Description

Pomalidomide-C6-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based CRBN ligand and linker used in PROTAC technology.

Key Properties

• CAS Number: 2375194-37-7
• MW: 408.88
• Purity: >98% (HPLC)
• Formula: C₁₉H₂₅ClN₄O₄
• SMILES: Cl.NCCCCCCNc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12
• Target: ATPase|Calcium Channel|PAFR|Potassium Channel

Bioactivity

• In Vitro:
  PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Pomalidomide-C6-NH2 hydrochloride

Quick Database Links

Gene Symbol

ATPase|Calcium Channel|PAFR|Potassium Channel