Thalidomide-NH-C6-NH2 hydrochloride

SKU: orb1940282

Description

Pomalidomide-C6-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based CRBN ligand and linker used in PROTAC technology.

Research Area

Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	2375194-37-7
MW	408.88
Purity	>98% (HPLC)
Formula	C₁₉H₂₅ClN₄O₄
SMILES	Cl.NCCCCCCNc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12
Target	ATPase\|Calcium Channel\|PAFR\|Potassium Channel

Bioactivity

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In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Storage & Handling

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Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Pomalidomide-C6-NH2 hydrochloride

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Quick Database Links

Gene Symbol

ATPase|Calcium Channel|PAFR|Potassium Channel

Protocol Information

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Purity:	99.27% (May vary between batches)
CAS Number:	2375194-37-7
MW:	408.88
Formula:	C₁₉H₂₅ClN₄O₄