TFC-007

SKU: orb1702737

Description

TFC-007 is a potent and selective inhibitor of hematopoietic prostaglandin D synthase (H-PGDS), effectively suppressing inflammatory mediators. It serves as a key precursor for synthesizing H-PGDS-targeting PROTAC degraders and has been utilized in research models, such as cedar pollen-induced allergic rhinitis in guinea pigs, to study allergic inflammation pathways.

Research Area

Immunology & Inflammation, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 927878-49-7
• MW: 487.55
• Purity: 98.07% (May vary between batches)
• Formula: C₂₇H₂₉N₅O₄
• SMILES: O=C(NC1=CC=C(C=C1)N2CCC(C(=O)N3CCOCC3)CC2)C4=CN=C(N=C4)OC=5C=CC=CC5
• Target: Ligands for Target Protein for PROTAC,PGE Synthase,Ligands for E3 Ligase
• Solubility: DMSO:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• Target IC50:
  HPGDS:83 nM
• In Vitro:
  TFC-007 is a highly selective inhibitor of hematopoietic prostaglandin D synthase (H-PGDS), inhibiting H-PGDS enzyme with high activity and an IC50 value of 83 nM.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

TFC 007, TFC007, TFC-007

Compound Identifiers

PubChem CID

16040067