TFAP

SKU: orb1302688

Description

TFAP is a selective cyclooxygenase-1 (COX-1) inhibitor with the chemical name N-(5-Aminopyridin-2-yl)-4-(trifluoromethyl)benzamide. This small molecule is used in research to investigate COX-1-specific roles in platelet aggregation, inflammation, and pain pathways in both cellular and animal models.

Research Area

Immunology & Inflammation, Metabolism Research, Neuroscience

Key Properties

• CAS Number: 1011244-68-0
• MW: 281.23
• Purity: 100.00%
• Formula: C₁₃H₁₀F₃N₃O
• SMILES: Nc1ccc(NC(=O)c2ccc(cc2)C(F)(F)F)nc1
• Target: Endogenous Metabolite,COX
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.11 mM);DMSO:50 mg/mL (177.79 mM)

Bioactivity

• Target IC50:
  COX-1:0.8 μM
• In Vitro:
  TFAP is a selective cyclooxygenase-1 (COX-1) inhibitor with an IC50 of 0.8 μM and an IC50 greater than 200 μM against [COX-2].

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

TFAP, Cyclooxygenase, COX-1, COX, Endogenous Metabolite, EndogenousMetabolite, Inhibitor, inhibit, N-(5-Aminopyridin-2-yl)-4-(trifluoromethyl)benzamide

Compound Identifiers

PubChem CID

24752865