Tetroquinone

SKU: orb1225316

Description

Tetrahydroxy-1,4-benzoquinone, also called tetrahydroxy-p-benzoquinone, tetrahydroxybenzoquinone, or tetrahydroxyquinone (THBQ, THQ), is an organic compound with formula C6O2(OH)4. Its molecular structure consists of a cyclohexadiene ring with four hydroxyl groups and two ketone groups in opposite (para) positions.

Key Properties

• CAS Number: 319-89-1
• MW: 172.09
• Purity: >98% (HPLC)
• Formula: C₆H₄O₆
• SMILES: O=C1C(O)=C(O)C(C(O)=C1O)=O
• Target: Others
• Solubility: DMSO: 10 mM

Bioactivity

• In Vitro:
  Tetrahydroxyquinone (100-500 μM; 24 hours; HL60 cells) treatment shows cytotoxic for HL60 leukaemia cells by total protein content (IC50 of 20 μM), phosphatase activity (IC50 of 40 μM), or by MTT assay (IC50 of 45 μM). Tetrahydroxyquinone is an efficient inducer of ROS production in HL60 leukaemia cells. Tetrahydroxyquinone efficiently activates caspase 3 in concentration in excess of 25 μM, stimulates DNA fragmentation at the same concentration and provoke phosphatidylserine exposure. Tetrahydroxyquinone induces the release of cytochrome c from the mitochondria at concentration as low as 25 μM. Tetrahydroxyquinone treatment also causes increase of phosphorylation of Ser473 in protein kinase B (the Bad kinase for Ser112). Cell Viability Assay Cell line: HL60 leukaemia cells. Concentration: 100 μM, 200 μM, 300 μM, 400 μM, 500 μM. Incubation time: 24 hours. Result: Showed cytotoxic for HL60 leukaemia cells.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Tetroquinone | Tetroquinona | Tetroquinonum

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Gene Symbol

Others