Tetracycline

SKU: orb1224496

Description

Tetracycline is a naphthacene antibiotic that inhibits amino acyltrna. binding during protein synthesis.(In Vitro):Tetracycline shows susceptibilfty of V. vulnlflcus strain B3547 with MIC value of 0.5g/mL.Tetracycline inhibits the L-amyloid aggregates formation and disassembles the pre-formed fibrils.(In Vivo):Tetracycline (3 mg/kg; i.p. every 12 h until survive) survives mice from bacteremia.

Key Properties

• CAS Number: 60-54-8
• MW: 444.43
• Purity: >98% (HPLC)
• Formula: C₂₂H₂₄N₂O₈
• SMILES: C[C@@]1([C@H]2C[C@H]3[C@@H](C(=O)C(=C([C@]3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O
• Target: Major prion protein| 16S ribosome| 30S ribosome
• Solubility: Soluble in Water

Bioactivity

• In Vivo:
  Animal model: Female ICR mice weight 30 to 40 g with V. vulnificus strain B3547 infection. Dosage: 3 mg/kg. Administration: Intraperitoneal injection; 3 mg/kg every 12h until survive. Result: Inhibited the growth of human CNE-2 xenografts in nude mice.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Major prion protein| 16S ribosome| 30S ribosome