Tetracaine hydrochloride

SKU: orb1226441

Description

Tetracaine hydrochloride (Pontocaine) is a hydrochloride salt form of tetracaine which is a potent local anaesthetic and a channel function allosteric inhibitor. Tetracaine hydrochloride (Pontocaine) is used to block temporarily the pain "message" that is sent along the nerves that connect the eyes to the brain. Tetracaine hydrochloride (Pontocaine) is mainly used topically in ophthalmology and as an antipruritic, and it has been used in spinal anesthesia. (In Vitro):Tetracaine hydrochloride (Amethocaine hydrochloride) is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores. Tetracaine hydrochloride is an allosteric blocker of channel function. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely.

Key Properties

• CAS Number: 136-47-0
• MW: 300.83
• Purity: >98% (HPLC)
• Formula: C₁₅H₂₄N₂O₂·HCl
• SMILES: Cl.CCCCNC1=CC=C(C=C1)C(=O)OCCN(C)C
• Target: Sodium Channel
• Solubility: Ethanol: 30 mg/mL (99.72 mM); Water: 60 mg/mL (199.45 mM); DMSO: 60 mg/mL (199.45 mM)

Bioactivity

• In Vitro:
  Tetracaine hydrochloride (Amethocaine hydrochloride) is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores. Tetracaine hydrochloride is an allosteric blocker of channel function. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Sodium Channel