Tenidap

SKU: orb1706556

Description

Tenidap (CP-66248) is a dual inhibitor of COX-1 and the anion transporter SLC26A3, exhibiting anti-inflammatory and analgesic properties. It has been utilized in research on rheumatoid arthritis, with studies investigating its mechanisms in both cellular and animal models of inflammation.

Research Area

Cell Biology, Immunology & Inflammation, Molecular Biology, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 120210-48-2
• MW: 320.75
• Purity: 98.56% (May vary between batches)
• Formula: C₁₄H₉ClN₂O₃S
• SMILES: NC(=O)N1C(=O)\C(=C(/O)c2cccs2)c2cc(Cl)ccc12
• Target: DNA/RNA Synthesis,COX
• Solubility: DMSO:20 mg/mL (62.35 mM)

Bioactivity

• Target IC50:
  COX-2:1.2 μM|COX-1:0.03 μM
• In Vivo:
  After sustained epilepsy (SE) induced by trichostatin in male Wistar rats, Tenidap was administered at 10 mg / kg daily for 10 days, 46.88 ± 10.70 neurons survived in the tenidap-SE group, and 37.75 ± 8.78 neurons survived in the tenidap-SE group, Tenidap significantly inhibited the hippocampal expression of COX-2 in the hippocampus, especially in the CA3 region.
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• In Vitro:
  The human astrocytoma cell line U373 MG was incubated with 0.1-100 µM tenidap for 30 min and then stimulated with 50 µM C6-ceramide for 24 h. Tenidap inhibited the dose-dependent ceramide-induced IL-6 protein synthesis in U373 human astrocytoma cells.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

COX-1, COX-2, CP 66248, CP66248, CP-66248, DNASynthesis, DNA Synthesis, DNA synthesis, Tenidap, RNA Synthesis, RNASynthesis

Compound Identifiers

PubChem CID

60712