Tempone

SKU: orb1985050

Description

Tempone is an aminooxyalkane compound that functions as a scavenger of free radicals and reactive oxygen species (ROS). It is utilized in oxidative stress research, including in vitro assays and in vivo studies such as those demonstrating its hypotensive effect in hypertensive rat models.

Research Area

Immunology & Inflammation

Key Properties

• CAS Number: 2896-70-0
• MW: 170.23
• Purity: 98.18% (May vary between batches)
• Formula: C₉H₁₆NO₂
• SMILES: CC1(C)CC(=O)CC(C)(C)N1[O]
• Target: ROS,Others
• Solubility: Ethanol:30 mg/mL (176.23 mM);PBS (pH 7.2):10 mg/mL (58.74 mM);DMF:30 mg/mL (176.23 mM);DMSO:45 mg/mL (264.35 mM)

Bioactivity

• In Vivo:
  Tempone (100 mg/kg i.v. bolus followed by 30 mg/kg i.v. infusion; rats) significantly improved both glomerular and tubular function (serum urea, creatinine, creatinine clearance, and fractional excretion of Na(+)) in a dose-dependent manner and significantly attenuated the reperfusion-injury associated with I/R (urinary N-acetyl-beta-D-glucosaminidase, aspartate aminotransferase, assessment of renal histology). Tempone also markedly reduced the immunohistochemical evidence of the formation of nitrotyrosine and poly(ADP-ribose), indicating a reduction of nitrosative and oxidative stress, respectively. Importantly, in contrast to its in vivo metabolite TEMPOL (which also provided protective effects against renal I/R and oxidative stress of PT cells), Tempone reduced renal dysfunction and injury without causing a significant reduction in blood pressure upon administration. These results suggest, for the first time, that Tempone can reduce the renal dysfunction and injury caused by I/R and the injury caused to PT cells by oxidative stress without producing the adverse cardiovascular effects observed when using other nitroxyl radicals.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

4-Oxo-tempo, ROS, Tempone

Compound Identifiers

PubChem CID

98642