Telaprevir

SKU: orb1225111

Description

A potent, selective, covalent, orally bioavailable inhibitor of HCV NS3/4A protease with Ki of 7 nM; demonstrates excellent antiviral activity both in genotype 1b HCV replicon cells (IC50=354 nM) and in human fetal hepatocytes (IC50=280 nM); shows excellent viral inhibition in vivo with favorable pharmacokinetic profile.HCV Infection Approved.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 402957-28-2
• MW: 679.8493
• Purity: >98% (HPLC)
• Formula: C₃₆H₅₃N₇O₆
• SMILES: O=C([C@@H]1[C@](CCC2)([H])[C@]2([H])CN1C([C@@H](NC([C@H](C3CCCCC3)NC(C4=NC=CN=C4)=O)=O)C(C)(C)C)=O)N[C@@H](CCC)C(C(NC5CC5)=O)=O
• Target: HCV
• Solubility: 10 mM in DMSO

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

VX-950 | VX950 | VX 950

Quick Database Links

Gene Symbol

HCV