Tefinostat

SKU: orb1706559

Description

Tefinostat (CHR-2845) is a selective HDAC inhibitor activated intracellularly by human carboxylesterase-1 (hCE-1) to CHR-2847, targeting monocytes and macrophages. Its antitumor activity is under investigation for leukemia and hematologic malignancies, supported by in vitro and in vivo research models.

Research Area

Cell Biology, Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 914382-60-8
• MW: 495.61
• Purity: 99.41% (May vary between batches)
• Formula: C₂₈H₃₇N₃O₅
• SMILES: ONC(=O)CCCCCCC(=O)Nc1ccc(CN[C@H](C(=O)OC2CCCC2)c2ccccc2)cc1
• Target: HDAC,Apoptosis
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (6.66 mM);DMSO:90 mg/mL (181.59 mM)

Bioactivity

• In Vitro:
  Tefinostat (1-4 nM; AML cell lines) demonstrates efficacy in AML cell lines, including HL60 (M2 FAB type), MV411 (M4, FLT3-ITD), OCIAML3 (M4 NPM1mut), and THP1 (M5), with EC50 values of 2.3 μM, 57 nM, 110 nM, and 560 nM, respectively.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CHR 2845, CHR2845, CHR-2845, HDAC, Tefinostat

Compound Identifiers

PubChem CID

15940949