Tebuconazole-d9

• Catalog Number: orb1738338
• Category: Small Molecules
• Description: Tebuconazole-d9
• CAS Number: 1246818-83-6
• Purity: 0.98
• MW: 316.87
• SMILES: C(CN1C=NC=N1)(CCC2=CC=C(Cl)C=C2)(C(C([2H])([2H])[2H])(C([2H])([2H])[2H])C([2H])([2H])[2H])O
• Formula: C₁₆H₁₃D₉ClN₃O
• Biological Activity: Tebuconazole-d9 is intended for use as an internal standard for the quantification of tebuconazole by GC- or LC-MS. Tebuconazole is a triazole fungicide that is active against both seed and foliar fungi. It inhibits 14α-demethylase isolated from U. maydis and S. bicolor with IC50 values of 0.05 and 0.16 nM, respectively. It inhibits the androgenic effect of the androgen receptor agonist DHT (IC20 = 2.89 µM) and is cytotoxic (EC20 = 38.9 µM) in an MDA-kb2 assay. Tebuconazole (50 and 100 mg/kg per day) administered during gestation reduces testosterone levels and increases testicular levels of progesterone and 17α-hydroxyprogesterone in male rat fetuses. It has a feminizing effect on male pups and a virializing effect on female pups. When administered to rats gestationally through postnatal day 42, tebuconazole (20 and 60 mg/kg per day) leads to cell death of pyramidal cells in the CA3-4 region of the hippocampus and layer V of the cortex concomitant with impairment in learning......
• Note: For research use only
• Expiration Date: 12 months from date of receipt.