TD-428

SKU: orb1990251

Description

TD-428 is a potent and selective BET PROTAC degrader that links JQ1 to a CRBN ligand, inducing efficient BRD4 degradation with a DC50 of 0.32 nM. It is a valuable chemical probe for studying BET protein function in cancer and inflammation research, applicable in both cellular and in vivo models.

Research Area

Epigenetics & Chromatin, Pharmacology & Drug Discovery

Key Properties

• MW: 879.38
• Formula: C₄₃H₄₃ClN₁₀O₇S
• SMILES: O=C(NC1=CC(OCCOCCOCCNC2=C3C(N=NN(C(CC4)C(NC4=O)=O)C3=O)=CC=C2)=CC=C1)C[C@H]5C6=NN=C(C)N6C7=C(C(C)=C(C)S7)C(C8=CC=C(Cl)C=C8)=N5
• Target: PROTACs,Epigenetic Reader Domain

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

137628680