TCRS-417

SKU: orb1943737

Description

TCRS-417 (T417) is a cell-permeable small molecule inhibitor that disrupts the interaction between PBX1 transcription factors and DNA. It is a valuable research tool for studying PBX1 function in models of autoimmune and neurodegenerative diseases, applicable in both in vitro and in vivo experimental systems.

Research Area

Cell Biology, Molecular Biology, Signal Transduction

Key Properties

• CAS Number: 2032123-28-5
• MW: 446.43
• Formula: C₂₅H₁₉FN₂O₅
• SMILES: O=C(NC1=CC=C(OCC(=O)NC2=CC=C(O)C(O)=C2)C=3C=CC=CC13)C=4C=CC=C(F)C4
• Target: Others
• Solubility: DMSO:80 mg/mL (179.2 mM)

Bioactivity

• In Vivo:
  TCRS-417(2.5 mg/kg intraperitoneally injected) inhibited tumor growth in mice xenografted with SKOV3CRLuc.
• In Vitro:
  TCRS-417 (0 μM, 2.5 μM, 5 μM, 7.5 μM and 10 μM, 48h) can effectively interfere with PBX1-DNA interactions.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

T 417, T417, TCRS417

Compound Identifiers

PubChem CID

122651081