TC-S 7009

SKU: orb1706567

Description

TC-S 7009 is a potent, selective HIF-2α inhibitor (Kd: 81 nM) that disrupts heterodimerization and DNA binding, suppressing target gene expression. It is widely used in vitro and in vivo for research on renal cell carcinoma, pulmonary hypertension, and other HIF-2α-driven pathologies.

Research Area

Cardiovascular Research, Epigenetics & Chromatin, Metabolism Research

Key Properties

• CAS Number: 1422955-31-4
• MW: 308.65
• Purity: 99.89%
• Formula: C₁₂H₆ClFN₄O₃
• SMILES: [O-][N+](=O)c1c(Nc2cc(F)cc(Cl)c2)ccc2nonc12
• Target: HIF,HIF/HIF Prolyl-Hydroxylase
• Solubility: DMSO:45 mg/mL (145.8 mM)

Bioactivity

• Target IC50:
  HIF2α:81 nM(kd)
• In Vitro:
  TC-S 7009 (50 μM) treatment almost fully inhibits hypoxia-induced NFATc2 nuclear translocation. TC-S 7009 (0-100 µM; 72 hours; HPF cells) treatment displays greater inhibition of cell proliferation in hypoxic conditions than that in normoxic conditions .

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

HIF-2α, TC S 7009, TCS 7009, TC-S 7009, TC-S7009, TC-S-7009

Compound Identifiers

PubChem CID

70697712