HIF-2a-I2

SKU: orb1706567

Description

TC-S 7009 is a potent, selective HIF-2α inhibitor (Kd: 81 nM) that disrupts heterodimerization and DNA binding, suppressing target gene expression. It is widely used in vitro and in vivo for research on renal cell carcinoma, pulmonary hypertension, and other HIF-2α-driven pathologies.

Research Area

Cell Biology

Key Properties

• CAS Number: 1422955-31-4
• MW: 308.65
• Purity: >98%
• Formula: C₁₂H₆ClFN₄O₃
• SMILES: [O-][N+](=O)c1c(Nc2cc(F)cc(Cl)c2)ccc2nonc12
• Target: Transcription factor
• Solubility: Soluble in DMSO (up to 30 mg/ml) or in DMF (up to 35 mg/ml)

Bioactivity

• Target IC50:
  HIF2α:81 nM(kd)
• In Vitro:
  TC-S 7009 (50 μM) treatment almost fully inhibits hypoxia-induced NFATc2 nuclear translocation. TC-S 7009 (0-100 µM; 72 hours; HPF cells) treatment displays greater inhibition of cell proliferation in hypoxic conditions than that in normoxic conditions .
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

TC-S 7009

Compound Identifiers

PubChem CID

70697712