Taurodeoxycholic acid

SKU: orb1982110

Description

Taurodeoxycholic acid is a taurine-conjugated bile acid metabolite that stabilizes mitochondrial membranes and exhibits anti-apoptotic activity. It is utilized in neuroscience research, including studies of Huntington's disease models, for its neuroprotective properties in both in vitro and in vivo experimental systems.

Research Area

Cell Biology, Epigenetics & Chromatin, Metabolism Research, Molecular Biology, Pharmacology & Drug Discovery, Protein Biochemistry, Signal Transduction

Images & Validation

• Application Notes:
  This product is chemically synthesized.

Key Properties

• CAS Number: 516-50-7
• MW: 499.7
• Purity: 99.22% (May vary between batches)
• Formula: C₂₆H₄₅NO₆S
• SMILES: C[C@@]12[C@]([C@]3([C@@]([C@]4(C)[C@](CC3)(C[C@H](O)CC4)[H])(C[C@@H]1O)[H])[H])(CC[C@@]2([C@@H](CCC(NCCS(=O)(=O)O)=O)C)[H])[H]
• Target: Apoptosis|||Calcium Channel|||Caspase
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4 mM);DMSO:50 mg/mL (100.06 mM)

Bioactivity

• In Vivo:
  Taurodeoxycholic acid (50 mg/kg; i.p.; once daily for 34 days; Huntington's disease model in mice) prevents neuropathology and associated behavioral deficits in a rat model of Huntington's disease (HD). Taurodeoxycholic acid (500 mg/kg; subcutaneous injection; every 3 days for 7 weeks; Huntington's disease model in mice) resulted in a significant reduction in striatal neuropathology in R6/2 transgenic HD mice.
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• In Vitro:
  Taurodeoxycholic acid (50, 100 μM; 4 h) increases oligonuclear DNA cleavage and nuclear apoptosis in primary human hepatocytes. Taurodeoxycholic acid (400 μM; 18-24 h) increases DNA fragmentation and PARP cleavage and induces apoptosis in human liver-derived Huh7 cells.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Taurodeoxychloic acid, Taurodeoxycholic acid, Apoptosis, CalciumChannel, Calcium Channel, Ca(2+) receptor, Caspase

Compound Identifiers

PubChem CID

2733768