TAT-ANK

• Catalog Number: orb1147034
• Category: Proteins
• Description: Dll4-Notch1 inhibitor; Cell penetrating peptides.
• Modifications: None
• Structure: H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Gln-Thr-Leu-Gln-Ala-Glu-Leu-Leu-Val-Val-Tyr-Gly-Ala-OH
• Target Areas: Nuclear receptor modulators, Protein-protein interactions
• Form/Appearance: Freeze dried solid
• Purity: > 95% by hplc
• MW: 2946.45 Da
• Formula: C₁₂₈H₂₂₁N₄₇O₃₃
• Solubility (25°C): Soluble in 50% DMSO and 50% sterile H2O
• Protein Sequence: H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Gln-Thr-Leu-Gln-Ala-Glu-Leu-Leu-Val-Val-Tyr-Gly-Ala-OH
• Storage: Store dry, frozen and in the dark
• Alternative names: ANK peptideTAT-ANK, YGRKKRRQRRRQTLQAELLVVYGA
• Background: TAT-ANK is a peptide derived from amino acid residues 179-191 of the G-protein coupled receptor kinase interacting protein-1 (GIT1) ankyrin domain, which are are crucial for GIT1 binding tothe Notch transcription repressor RBP-J. In vitro, application of TAT-ANK significantly inhibits Delta-like 4 (Dll4) expression andNotch 1 activation in human umbilical vein endothelialcells (HUVECs) by competing with activated Notch1 binding to RBP-J, and in mouse models, TAT-ANK reduces tumour size through impairing tumour angiogenesis.
• Note: For research use only
• Expiration Date: 12 months from date of receipt.