TAS120

SKU: orb1221318

Description

TAS-120 is a novel potent and highly selective FGFR inhibitor used for antitumor treatment.(In Vitro):Futibatinib (TAS-120) covalently binds to a highly conserved P-loop cysteine residue in the ATP pocket of FGFR.(In Vivo):Futibatinib (TAS-120) (3, 30, 100 mg/kg/day, p.o.) exerts an anti-tumor effect in mice. Futibatinib (TAS-120) shows anti-tumor effect by administering at moderate intervals, such as intermittent administration of every other day dosing and 2 times/week, and reducing the sustained elevation and weight suppression blood phosphorus level, and take a antitumor effective as daily administration.

Key Properties

• CAS Number: 1448169-71-8
• MW: 418.45
• Purity: >98% (HPLC)
• Formula: C₂₂H₂₂N₆O₃
• SMILES: COc1cc(OC)cc(c1)C#Cc1nn([C@H]2CCN(C2)C(=O)C=C)c2ncnc(N)c12
• Target: FGFR
• Solubility: DMSO:≥ 29 mg/mL (69.30 mM)

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Futibatinib | FGFR-IN-1

Quick Database Links

Gene Symbol

FGFR