Tannic acid

SKU: orb1310279

Description

Tannic acid

Research Area

Cell Biology, Immunology & Inflammation, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1401-55-4
• Purity: 95.00%
• Target: CXCR,Potassium Channel
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL;H2O:17.24 mg/mL;DMSO:270 mg/mL

Bioactivity

• Target IC50:
  A549 cells (48 h):20-40 µM|tyrosine kinase activity of epidermal growth factor receptor (EGFr):3 23 nM|ERG channel (human):3.4 μM|CXCL12 cells:7.5 μg mL A549 cells (24 h):40-60 µM|α-amylase:3.46 μg/ml
• In Vivo:
  METHODS: To investigat the effects on oxidative stress mice, Tannic acid (2.5-10 mg/kg) was administered orally to diquat-induced oxidative stress C57BL/6J mouse model once daily for ten days. Results: Tannic acid pretreatment in the oxidative stress mouse model failed to alter antioxidant enzymes but modulated jejunal morphology, colon length, antioxidant pathways, and intestinal barrier in the diquat oxidative model.
• In Vitro:
  METHODS: Rat cardiomyocytes H9C2 were treated with Tannic acid (5-50 µM) for 24 h. Cell viability was determined by CCK-8 Assay. Results: Treatment of H9C2 cells with Tannic acid concentration ≥ 30 µM resulted in a significant decrease in cell viability. METHODS: Human lung cancer cells A549 were treated with Tannic acid (20-60 µM) for 24-48 h. Cell cycle was measured by Flow cytometry. Results: Tannic acid inhibited cell viability in a dose-dependent manner at 24 h, with higher Inhibition after 48 h the IC50 Values for Tannic acid were estimated to be in the range of 40-60 µM at 24 h and 20-40 µM at 48 h. METHODS: Human lung cancer cells A549 were treated with Tannic acid (20-60 µM) for 24-48 h. Cell cycle was measured by Flow cytometry.

Storage & Handling

• Storage: keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

hERG, Gallotannic acid, CXCR, PotassiumChannel, Potassium Channel, Tannic acid

Quick Database Links

Gene Symbol

CXCR,Potassium Channel