Taltirelin acetate

SKU: orb1309037

Description

Taltirelin acetate (TA-0910 acetate) is a potent superagonist of the thyrotropin-releasing hormone receptor (TRH-R), with an EC50 of 36 nM for stimulating intracellular calcium release. This compound is utilized in neuroscience research, particularly in studies investigating neurodegenerative diseases like spinocerebellar degeneration, in both cellular and animal models.

Research Area

Cell Biology, Metabolism Research

Key Properties

• CAS Number: 1549593-23-8
• MW: 465.46
• Purity: 99.44% (May vary between batches)
• Formula: C₁₉H₂₇N₇O₇
• SMILES: CC(O)=O.CN1C(=O)C[C@H](NC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O
• Target: Thyroid hormone receptor(THR),Apoptosis
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (8.59 mM);DMSO:125 mg/mL (268.55 mM)

Bioactivity

• Target IC50:
  TRHR:910 nM (IC50)

Storage & Handling

• Storage: store at low temperature | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, TA 0910, TA 0910 Acetate, TA0910, TA-0910, TA0910 Acetate, TA-0910 Acetate, TA-0910 acetate, Taltirelin, Taltirelin acetate, Taltirelin Acetate, Thyrotropin-releasing hormone receptor, Thyroid Hormone Receptor, Thyroid hormone receptor, Thyroid hormone receptor(THR), Thyroidhormonereceptor(THR), Thyroidhormonereceptor, THR

Compound Identifiers

PubChem CID

86346477