Talaroconvolutin A

SKU: orb3141847

Description

Talaroconvolutin A is an inducer of ferroptosis (ferroptosis) that operates by elevating reactive oxygen species (ROS) levels instead of acting through the GPX4 pathway. It decreases the expression of the solute carrier family 7 member 11 (SLC7A11) and increases the expression of arachidonate lipoxygenase 3 (ALOXE3). This compound inhibits the growth of colorectal cancer cells HCT116 and bladder cancer cells SW480, with IC50 values of 1.22 μM and 1.4 μM, respectively. Talaroconvolutin A is applicable in studies related to colorectal and bladder cancers.

Research Area

Cell Biology, Immunology & Inflammation, Signal Transduction

Key Properties

• CAS Number: 273199-42-1
• MW: 487.67
• Formula: C₃₂H₄₁NO₃
• SMILES: C(=O)([C@H]1[C@]2([C@](C)(C=C(C)[C@H]1\C(=C\[C@H](CC)C)\C)C[C@H](C)CC2)[H])C3=C\C(=C\C4=CC=C(O)C=C4)\NC3=O
• Target: Ferroptosis,p38 MAPK,ROS

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Ferroptosis,p38 MAPK,ROS