Tafenoquine Succinate

SKU: orb1309033

Description

Tafenoquine Succinate (WR 238605) is an 8-aminoquinoline compound used for malaria prophylaxis. It is widely employed in research to study its antiplasmodial mechanisms and efficacy in both in vitro assays and in vivo animal models of malaria infection.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 106635-81-8
• MW: 581.58
• Purity: 99.84% (May vary between batches)
• Formula: C₂₈H₃₄F₃N₃O₇
• SMILES: OC(=O)CCC(O)=O.COc1cc(C)c2c(Oc3cccc(c3)C(F)(F)F)c(OC)cc(NC(C)CCCN)c2n1
• Target: Parasite,Others
• Solubility: DMSO:135 mg/mL (232.13 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (6.88 mM)

Bioactivity

• In Vivo:
  When tested at two times its ED100 (6 mg/kg), Tafenoquine anti-malarial activity is partially restored in humanized/CYP 2D6 knock-in mice .

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

WR238605, WR-238605, WR 238605, WR 238605 (Succinate), Tafenoquine, Tafenoquine Succinate, antimalarial, Anti-malarial, inhibit, Parasite, Inhibitor

Compound Identifiers

PubChem CID

163761