SYM2206

SKU: orb1706590

Description

SYM2206 is a low-affinity, non-competitive AMPA receptor antagonist (IC50 = 1.6 µM) that demonstrates anticancer properties. It functions by inhibiting Nav1.6-mediated sustained currents, leading to reduced survival in pancreatic cancer cells in vitro, highlighting its utility in neurobiological and oncology research.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 173952-44-8
• MW: 366.41
• Purity: 99.88%
• Formula: C₂₀H₂₂N₄O₃
• SMILES: CCCNC(=O)N1N=C(c2ccc(N)cc2)c2cc3OCOc3cc2C1C
• Target: iGluR,Sodium Channel
• Solubility: DMSO:100 mg/mL (272.92 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (10.92 mM)

Bioactivity

• Target IC50:
  AMPA:1.6 μM

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AMPAR, Nav1.6 channel, SYM 2206, SYM2206, SYM-2206, SodiumChannel, Sodium Channel

Compound Identifiers

PubChem CID

5039877