Suvecaltamide

SKU: orb1301636

Description

Suvecaltamide (MK-8998) is a potent and selective small molecule inhibitor of T-type calcium channels. This compound is a valuable research tool for investigating the role of these channels in neurological disorders, including epilepsy and neuropathic pain, in both in vitro and in vivo models.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 953778-58-0
• MW: 380.4
• Purity: 99.70% (May vary between batches)
• Formula: C₂₀H₂₃F₃N₂O₂
• SMILES: CC(C)c1ccc(CC(=O)N[C@H](C)c2ccc(OCC(F)(F)F)cn2)cc1
• Target: Calcium Channel
• Solubility: DMSO:100 mg/mL (262.88 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (10.52 mM)

Bioactivity

• In Vivo:
  MK-8998 displayed in vivo efficacy in rodent models of epilepsy and sleep.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

T-type calcium channel, Suvecaltamide, CalciumChannel, Ca channels, Ca2+ channels, Calcium Channel, Inhibitor, inhibit, MK8998, MK-8998, MK 8998

Compound Identifiers

PubChem CID

24765479