Sulmazole

SKU: orb1699214

Description

Sulmazole (AR-L 115-BS) is a small molecule that acts as a cGMP-PDE inhibitor and a competitive A1 adenosine receptor antagonist. It has been investigated in heart failure research, where studies report improvements in cardiac index and reductions in pulmonary capillary wedge pressure in experimental models.

Research Area

Infectious Disease & Virology, Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 73384-60-8
• MW: 287.34
• Purity: 97.62% (May vary between batches)
• Formula: C₁₄H₁₃N₃O₂S
• SMILES: O(C)C1=C(C=CC(S(C)=O)=C1)C=2NC=3C(N2)=NC=CC3
• Target: PDE,Parasite,Adenosine Receptor
• Solubility: DMSO:6.25 mg/mL (21.75 mM)

Bioactivity

• In Vivo:
  In anaesthetized guinea pigs and dogs, bolus i.v. injections of sulmazole (0.1-10.0 mg kg-1) caused a significant, dose-related increase in ventricular dP/dt, and a reduction in diastolic blood pressure, with small increases in heart rate.
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• In Vitro:
  In cell-free biochemical assays, observed activities of sulmazole are cyclic nucleotide phosphodiesterase inhibitors with similar potencies and selectivities for the Type III enzyme (IC50=5.0 +/- 1.9 X 10(-5) M). sulmazole had little or no effects on sarcolemmal Na+/K+-ATPase, Ca2+ ATPase or Na+/Ca2+ exchange, and sulmazole had a small, stimulatory effect on myofibrillar ATPase.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PDE, cGMP, AR-L 115BS, AR-L 115-BS, A1, AdenosineReceptor, Adenosine Receptor, Sulmazole, Vardax

Compound Identifiers

PubChem CID

5353