Sulfathiazole

SKU: orb1310329

Description

Sulfathiazole is a short-acting sulfonamide antibiotic used in research. It serves as a key tool for studying antibacterial mechanisms and has been utilized in both in vitro microbiological assays and historical in vivo models of bacterial infection.

Research Area

Cell Biology, Infectious Disease & Virology

Key Properties

• CAS Number: 72-14-0
• MW: 255.32
• Purity: 99.97% (May vary between batches)
• Formula: C₉H₉N₃O₂S₂
• SMILES: Nc1ccc(cc1)S(=O)(=O)Nc1nccs1
• Target: Autophagy,Antibacterial,Antibiotic
• Solubility: DMSO:45 mg/mL (176.25 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• In Vitro:
  Sulfathiazole (20 μg/L) begins degrading between days 31 and 38 in one of two batch reactors with different wastewater matrices, at a faster rate than sulfamethoxazole or sulfamethazine in the nitrification process (S3). Recovery from spiked manure slurry samples is 64% for Sulfathiazole at pH 9. Sulfathiazole, with a pKa of 7.1 and retention times (tR) of 7.8, shows S/N values above 100 at the 1 mg/kg level. Its sorption to inorganic sorbents is pH-dependent, influenced by sorbate speciation and sorbent charge properties, with cations being most significant for clay mineral sorption, followed by neutral species. Sulfathiazole possesses at least five polymorphic forms: I, II, III, IV, and V and exists in the solid state in the imido form. Sulfathiazole (94.9 mg/L) significantly increases reactive oxygen species (ROS) generation and lipid peroxidation under ultraviolet B (UV-B) light exposure, upregulates alpha-esterase, hemoglobin, and vitellogenin mRNA, and significantly affects daphnid survival.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DHPS, 2-Sulfanilamidothiazole, Antibiotic, Bacterial, bacteria, Inhibitor, inhibit, Sulfathiazole, sulfonamide

Compound Identifiers

PubChem CID

5340