Sulfamethoxazole

SKU: orb1224143

Description

Sulfamethoxazole is a sulfonamide bacteriostatic antibiotic. Target: Antibacterial Sulfonamides are structural analogs and competitive antagonists of para-aminobenzoic acid (PABA). (In Vitro):Sulfonamides are structural analogs and competitive antagonists of para-aminobenzoic acid (PABA). They inhibit normal bacterial utilization of PABA for the synthesis of folic acid, an important metabolite in DNA synthesis. The effects seen are usually bacteriostatic in nature. Folic acid is not synthesized in humans, but is instead a dietary requirement. This allows for the selective toxicity to bacterial cells (or any cell dependent on synthesizing folic acid) over human cells. Bacterial resistance to sulfamethoxazole is caused by mutations in the enzymes involved in folic acid synthesis that prevent the drug from binding to it.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 723-46-6
• MW: 253.28
• Purity: >98% (HPLC)
• Formula: C₁₀H₁₁N₃O₃S
• SMILES: CC1=CC(NS(=O)(C2=CC=C(N)C=C2)=O)=NO1
• Target: Autophagy
• Solubility: Ethanol: 23 mg/mL (90.8 mM); DMSO: 51 mg/mL (201.35 mM)

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NSC 147832 | Ro 4-2130

Quick Database Links

Gene Symbol

Autophagy