Sulfamethazine sodium salt

SKU: orb1225773

Description

Sulfamethazine sodium salt is a sulfonamide antibacterial.(In Vivo):Sulfamethazine (80 mg/kg; intravenous injection; healthy female pigs) treatment significantly reduces α, β and AUC0->∞, significantly increases t1/2α, Vd and CIB, and upon a single intramuscular administration of 80 mg/kg of Sulfamethazine the absolute bioavailability in pigs is 1.01.

Key Properties

• CAS Number: 1981-58-4
• MW: 300.31
• Purity: >98% (HPLC)
• Formula: C₁₂H₁₃N₄NaO₂S
• SMILES: [Na+].CC1=CC(C)=NC([N-]S(=O)(=O)C2=CC=C(N)C=C2)=N1
• Target: Others
• Solubility: Soluble in Water

Bioactivity

• In Vivo:
  Sulfamethazine (80 mg/kg; intravenous injection; healthy female pigs) treatment significantly reduces α, β and AUC0->∞, significantly increases t1/2α, Vd and CIB, and upon a single intramuscular administration of 80 mg/kg of Sulfamethazine the absolute bioavailability in pigs is 1.01. Animal model: 19 healthy female pigs (6-week-old, 4.5-6.2 kg). Dosage: 80 mg/kg. Administration: Intravenous injection (Pharmacokinetic study). Result: The half-life in distribution phase is 0.23 h and half-lifes in eliminations phase is 9.8 h. α, β and the AUC0->∞ were significantly decreased and t1/2α, Vd and CIB were significantly increased, and the absolute bioavailability in pigs is 1.01.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

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