ST034307

SKU: orb1307724

Description

ST034307

Research Area

Neuroscience

Key Properties

• CAS Number: 133406-29-8
• MW: 297.95
• Purity: 99.28%
• Formula: C₁₀H₄Cl₄O₂
• SMILES: Clc1ccc2oc(cc(=O)c2c1)C(Cl)(Cl)Cl
• Target: Adenylyl Cyclase,AChR
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (3.36 mM);DMSO:50 mg/mL (167.81 mM)

Bioactivity

• Target IC50:
  AC type I:2.3 μM
• In Vivo:
  ST034307 shows an estimated median effective dose (E50) value for analgesia of 0.28 μg in the mouse pain model. ST034307 (0.25 μg) induces an obvious relief of CFA-induced inflammatory pain in mice .
• In Vitro:
  ST034307 obviously inhibits the forskolin- or isoproterenol-stimulated AC1 activity in HEK cells stably expressing AC1. ST034307 significantly inhibits the Ca2+/calmodulin-stimulated cAMP accumulation in the hippocampal homogenates. ST034307 dose-dependently inhibits both the development and the maintenance of the MOR-mediated sensitization of AC1. ST034307 reveals selective inhibition of AC1 and potentiates AC8 activity to a nonsignificant small extent. ST034307 potentiates phorbol 12-myristate 13-acetate (PMA)-stimulated cAMP production by AC2. ST034307 has no significant effects on wild-type HEK cells .

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AC1, Adenylate Cyclase, Adenylyl cyclase, adenylyl cyclase 1(AC1), Adenylylcyclase, inhibit, Inhibitor, ST 034307, ST034307, ST-034307

Compound Identifiers

PubChem CID

867466