SS-208

SKU: orb1307725

Description

SS-208 is a potent and selective HDAC6 inhibitor with an IC50 of 12 nM, demonstrating anti-tumor properties. Its selectivity profile makes it a valuable chemical probe for researching HDAC6's role in oncology, neurodegeneration, and immunology in both cellular and animal models.

Research Area

Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 2245942-72-5
• MW: 344.15
• Purity: 99.07% (May vary between batches)
• Formula: C₁₃H₁₁Cl₂N₃O₄
• SMILES: ONC(=O)c1cc(CCNC(=O)c2ccc(Cl)c(Cl)c2)on1
• Target: HDAC
• Solubility: DMSO:100 mg/mL (290.57 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (11.62 mM)

Bioactivity

• Target IC50:
  HDAC5:6.91 μM|HDAC7:8.34 μM|HDAC6:12 nM|HDAC1:1.39 μM|HDAC8:1.23 μM|HDAC11:5.12 μM
• In Vivo:
  In C57BL/6 mice injected immunogenic murine SM1 melanoma cells, SS-208 (25 mg/kg; i.p.) causes a significant reduction of the tumor growth.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

HDAC6, HDAC7, HDAC5, HDAC1, HDAC11, HDAC8, SS208, SS-208, SS 208

Compound Identifiers

PubChem CID

135348858